4-Methoxybenzoic Acid → 4-[2-Fluoro-5-(4-methoxy-benzoylamino)-benzylamino]-quinazoline-8-carboxylic acid amide

HRID 578709Notes

Reaction equation

HRID 578709 reaction equation
[CH3:1][O:2][C:3]1[CH:33]=[CH:32][C:6]([C:7]([N:9](C)[C:10]2[CH:11]=[C:12]([CH:28]=[CH:29][CH:30]=2)[CH2:13][NH:14][C:15]2[C:24]3[C:19](=[C:20]([C:25]([NH2:27])=[O:26])[CH:21]=[CH:22][CH:23]=3)[N:18]=[CH:17][N:16]=2)=[O:8])=[CH:5][CH:4]=1.NC1C=CC([F:43])=C(C=1)C#N.COC1C=CC(C(O)=O)=CC=1>>[F:43][C:28]1[CH:29]=[CH:30][C:10]([NH:9][C:7](=[O:8])[C:6]2[CH:32]=[CH:33][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[CH:11][C:12]=1[CH2:13][NH:14][C:15]1[C:24]2[C:19](=[C:20]([C:25]([NH2:27])=[O:26])[CH:21]=[CH:22][CH:23]=2)[N:18]=[CH:17][N:16]=1

Participants

4

Reactant 3

HCID 74784-Methoxybenzoic AcidHCID 27376735-Amino-2-fluorobenzonitrileHCID 667640754-{3-[(4-Methoxy-benzoyl)-methyl-amino]-benzylamino}-quinazoline-8-carboxylic acid amide

Product 1

HCID 667632904-[2-Fluoro-5-(4-methoxy-benzoylamino)-benzylamino]-quinazoline-8-carboxylic acid amide

Procedure

4-[2-Fluoro-5-(4-methoxy-benzoylamino)-benzylamino]-quinazoline-8-carboxylic acid amide was prepared according to example 4-{3-[(4-Methoxy-benzoyl)-methyl-amino]-benzylamino}-quinazoline-8-carboxylic acid amide, starting from 5-Amino-2-fluoro-benzonitrile and 4-methoxy-benzoic acid:

Sources & evidence

ORD record
ord-aa36483f51ad438d86e0037c48dad695
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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