Trifluoroacetic acid → HCID 89454155, compound

HRID 578727Notes

Reaction equation

HRID 578727 reaction equation
C([O:5][C:6](=[O:21])[CH2:7][CH:8]([P:15]([O:19][CH3:20])([O:17][CH3:18])=[O:16])[P:9]([O:13][CH3:14])([O:11][CH3:12])=[O:10])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH3:18][O:17][P:15]([CH:8]([P:9]([O:11][CH3:12])([O:13][CH3:14])=[O:10])[CH2:7][C:6]([OH:21])=[O:5])([O:19][CH3:20])=[O:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 89454165Tert-butyl 3,3-bis(dimethoxyphosphoryl)propanoate

Product 1

HCID 89454155HCID 89454155, compoundYield 105%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3,3-bis(dimethoxyphosphoryl)propanoic acid t-butyl ester (2.5 g) in dichloromethane (10 ml) was added trifluoroacetic acid. Stirring at room temperature was followed by evaporation of the volatiles in vacuo. Three cycles of vacuum evaporation of 5 ml portions of toluene gave 2.2 g product.

Workup

  1. customwas followed by evaporation of the volatiles in vacuo
  2. customThree cycles of vacuum evaporation of 5 ml portions of toluene

Sources & evidence

ORD record
ord-494a2a1a54f14168ab4197e16e7b49c4
Source dataset
uspto-grants-2015_05
Patent number
US09040637B2

Reaction notes

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