2-Fluorophenylboronic acid → HCID 71259057, compound

HRID 578760Notes

Reaction equation

HRID 578760 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[N:3]=1.[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1B(O)O>>[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:2]1[CH:11]=[CH:10][C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 27343542-Fluorophenylboronic acidHCID 19828469HCID 19828469, compound

Product 1

HCID 71259057HCID 71259057, compound

Procedure

Subsequently, Suzuki-Miyaura conditions were applied as in FIG. 8 using 2-bromo-5,6,7,8-tetrahydroquinoline and 2-fluorophenylboronic acid to obtain the 2-(2-fluorophenyl)-5,6,7,8-tetrahydroquinoline precursor as depicted in FIG. 10. After isolation and purification by flash chromatography, this viscous yellow-orange liquid solidifies at room temperature. In general, 2-(2-fluorophenyl)-pyridine derivatives wore prepared in high yields (over 92%).

Sources & evidence

ORD record
ord-6a1677c9eb3a4fa7a26e5118624e0007
Source dataset
uspto-grants-2015_05
Patent number
US09040704B2

Reaction notes

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