Ammonium Chloride → 1-(2-Fluoro-6-methoxyphenyl)ethanol

To a solution of 2-fluoro-6-methoxybenzaldehyde (0.5 g) in tetrahydrofuran (10 mL) was added methyllithium (1.15 mol/L diethyl ether solution, 3.4 mL) at −78° C., and the mixture was stirred at the same temperature for 1 hour. Then the mixture was stirred at room temperature for 30minutes. To the reaction mixture was added a saturated aqueous ammonium chloride solution, and the resulting mixture was extracted with diethyl ether. The extract was washed with water and brine successively, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (0.45 g).

1. stirringThen the mixture was stirred at room temperature for 30minutes
2. extractionthe resulting mixture was extracted with diethyl ether
3. washThe extract was washed with water and brine successively
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was removed under reduced pressure

ORD record

ord-f6a85eabb8784281baff17c71f46ed91

Source dataset

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09040693B2