(3-Chlorophenyl)boronic acid → 5-(Bromomethyl)-3-(3-chlorophenyl)-2-(difluoromethoxy)pyridine

HRID 578826Notes

Reaction equation

HRID 578826 reaction equation
Br[C:2]1[C:3]([O:10][CH:11]([F:13])[F:12])=[N:4][CH:5]=[C:6]([CH2:8][Br:9])[CH:7]=1.[Cl:14][C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1>>[Br:9][CH2:8][C:6]1[CH:7]=[C:2]([C:19]2[CH:18]=[CH:17][CH:16]=[C:15]([Cl:14])[CH:20]=2)[C:3]([O:10][CH:11]([F:13])[F:12])=[N:4][CH:5]=1

Participants

3

Reactant 2

HCID 2734323(3-Chlorophenyl)boronic acidHCID 904147933-Bromo-5-(bromomethyl)-2-(difluoromethoxy)pyridine

Product 1

HCID 904158565-(Bromomethyl)-3-(3-chlorophenyl)-2-(difluoromethoxy)pyridine

Procedure

The title compound was prepared in a manner analogous to Intermediate 10, using Intermediate 4 and 3-chlorophenyl boronic acid in Step 1, followed by bromination according to Step 3. [M+H]=348.17/350.15

Sources & evidence

ORD record
ord-da95885dd8054c62bce8ee8f7c6d2ee5
Source dataset
uspto-grants-2015_05
Patent number
US09040692B2

Reaction notes

Loading…