反应详情

Combined N-benzyl-6-chloronicotinamide (13 g, 52.8 mmol) and ethanol (60 mL) then added hydrazine hydrate (85%, 30 mL) drop wise at room temperature. After the addition, the solution was heated to reflux overnight. The reaction mixture was then concentrated to remove ethanol and a solid was obtained. The solid was collected by filtration, washed with EtOAc (3×20 mL), and dried under reduced pressure to give the title compound (10 g, 78%) as an off-yellow solid.

1. customwise at room temperature
2. additionAfter the addition
3. temperaturethe solution was heated
4. temperatureto reflux overnight
5. concentrationThe reaction mixture was then concentrated
6. customto remove ethanol
7. customa solid was obtained
8. filtrationThe solid was collected by filtration
9. washwashed with EtOAc (3×20 mL)
10. customdried under reduced pressure