1-(Methoxymethyl)cyclopropan-1-amine hydrochloride → HCID 178494694, compound

HRID 579027Notes

Reaction equation

HRID 579027 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][N:8]=2)[N:5]=[CH:4][C:3]=1[C:16]1[CH:21]=[CH:20][N:19]=[C:18]([O:22][CH3:23])[CH:17]=1.Cl.[CH3:25][O:26][CH2:27][C:28]1([NH2:31])[CH2:30][CH2:29]1>>[OH:1][C:2]1[N:6]([C:7]2[CH:15]=[CH:14][C:10]([C:11]([NH:31][C:28]3([CH2:27][O:26][CH3:25])[CH2:30][CH2:29]3)=[O:13])=[CH:9][N:8]=2)[N:5]=[CH:4][C:3]=1[C:16]1[CH:21]=[CH:20][N:19]=[C:18]([O:22][CH3:23])[CH:17]=1

Participants

3

Reactant 2

HCID 534072301-(Methoxymethyl)cyclopropan-1-amine hydrochlorideHCID 178487655HCID 178487655, compound

Product 1

HCID 178494694HCID 178494694, compound

Procedure

The title compound was prepared in a manner similar to Example 198 using 6-(5-hydroxy-4-(2-methoxypyridin-4-yl)-1H-pyrazol-1-yl)nicotinic acid and 1-(methoxymethyl)cyclopropanamine hydrochloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.80 (s, 4 H) 3.28 (s, 3 H) 3.48 (s, 2 H) 3.90 (s, 3 H) 7.49 (br. s., 1 H) 7.57 (d, J=5.3 Hz, 1 H) 8.08 (d, J=5.6 Hz, 1 H) 8.35-8.50 (m, 2 H) 8.68 (br. s., 1 H) 8.90 (t, J=1.4 Hz, 1 H) 8.98 (s, 1 H). MS m/z 396 [M+H]+.

Sources & evidence

ORD record
ord-d728a3c00aa1416ea4695ac5dea9cf3e
Source dataset
uspto-grants-2015_05
Patent number
US09040522B2

Reaction notes

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