3-Methoxy-N-methylpropan-1-amine → HCID 178495288, compound

HRID 579055Notes

Reaction equation

HRID 579055 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([O:24][CH3:25])[CH:4]=1)#[N:2].[CH3:26][O:27][CH2:28][CH2:29][CH2:30][NH:31][CH3:32]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([N:31]([CH2:30][CH2:29][CH2:28][O:27][CH3:26])[CH3:32])=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([O:24][CH3:25])[CH:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 125459843-Methoxy-N-methylpropan-1-amineHCID 178492256HCID 178492256, compound

Product 1

HCID 178495288HCID 178495288, compound

Procedure

The title compound was prepared in a manner similar to Example 227 using 6-(4-(4-cyano-2-methoxyphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 3-methoxy-N-methylpropan-1-amine 1H NMR (400 MHz, DMSO-d6) δ ppm 1.76-2.04 (m, 2 H) 3.09 (d, J=7.3 Hz, 3 H) 3.21 (s, 2 H) 3.36 (s, 2 H) 3.43-3.56 (m, 2 H) 3.65 (t, J=6.9 Hz, 1 H) 3.98 (s, 3 H) 7.31-7.36 (m, 2 H) 8.05 (br. s., 1 H) 8.28-8.64 (m, 3 H). MS m/z [M+H]+ 422.4.

Sources & evidence

ORD record
ord-05d8722b17424e36834115ce5ae38990
Source dataset
uspto-grants-2015_05
Patent number
US09040522B2

Reaction notes

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