反应详情

The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 1-methylpiperazine. 1H NMR (400 MHz, DMSO-d6) δ ppm 2.33 (d, J=2.53 Hz, 3 H) 2.84 (s, 3H) 3.17 (s, 8 H) 7.63 (d, J=7.58 Hz, 1 H) 7.70-7.79 (m, 1 H) 8.04-8.57 (m, 3 H) 8.59 (d, J=1.52 Hz, 1 H). ESI-MS m/z [M+H]+ 421.3.