反应详情

温度

65 °C

To the solution of 3-((S)-3-bromo-6-cyclohexyl-2-oxo-piperidin-1-yl)-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylic acid methyl ester (78 mg, 0.16 mmol, 1 equiv.) in DMF (1.0 mL) was added NaN3 (12 mg, 0.19 mmol, 1.2 equiv) and the resulting mixture was stirred at 65° C. for 18 hours. The solvent was then removed under vacuum. The residue was purified by silica gel column chromatography (EtOAc/Heptane, 10%˜60%) to give product 42 mg (yield 56%). MS: 442 [M+H+].

1. customThe solvent was then removed under vacuum
2. customThe residue was purified by silica gel column chromatography (EtOAc/Heptane, 10%˜60%)