HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Acetylpiperazine → 6-[(4-Acetyl-piperazin-1-yl)thiocarbonylamino]-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Acetylpiperazine | HCID 83795 | — |
| Reactant | 2-Tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole | HCID 15610362 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 6-[(4-Acetyl-piperazin-1-yl)thiocarbonylamino]-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole | HCID 54175931 | — |
Reaction Steps
A solution of 2.0 g of 2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole and 0.78 g of 1-acetyl-piperazine in 30 ml of chloroform is stirred for 30 minutes and the product triturated with petroleum ether to obtain 6-[(4-acetyl-piperazin-1-yl)thiocarbonylamino]-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole, melting at 187°-190°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05246927 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-c1cccb7f4ab14334a9142cd6bd51341b |
| Source note | uspto-grants-1993_09 |