Hydrochloric Acid → 2424-58-0

HRID 579413Notes

Reaction equation

HRID 579413 reaction equation
[CH2:1]([OH:4])[CH:2]=[CH2:3].[C:5]1(=[O:11])[O:10][C:8](=[O:9])[CH:7]=[CH:6]1.Cl>C(Cl)(Cl)Cl>[CH2:1]([O:4][C:5](=[O:11])/[CH:6]=[CH:7]\[C:8]([OH:10])=[O:9])[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7858Allyl AlcoholHCID 7923Maleic Anhydride

Product 1

HCID 139081352424-58-0Yield 85%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1.8 ml allyl alcohol (26 mmol, 1.3 eq.) were added to a 2 g solution of maleic anhydride (20 mmol) in chloroform. The reaction mixture was stirred at reflux for 5 h. The resulting solution was treated with 1N HCl and was extracted with chloroform. The organic extracts were washed with a saturated sodium chloride solution, dried on anhydrous magnesium sulfate and filtered. The solvent was evaporated at reduced pressure, and the residue obtained was identified as intermediate VI in the form of an oil (95% purity, 85% yield).

Workup

  1. temperatureat reflux for 5 h
  2. extractionwas extracted with chloroform
  3. washThe organic extracts were washed with a saturated sodium chloride solution
  4. dry with materialdried on anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customThe solvent was evaporated at reduced pressure
  7. customthe residue obtained

Sources & evidence

ORD record
ord-5f4aaf22d2fc47b3942bd39e05a83abb
Source dataset
uspto-grants-2015_05
Patent number
US09040701B2

Reaction notes

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