反应详情

温度

110 °C

A mixture of 3,5-dibromo-1-methyl-pyrazin-2-one (2.025 mmol; 542.4 mg), tert-butyl N-[(3S)-3-piperidyl]carbamate (2.025 mmol; 405.5 mg), cesium carbonate (4.049 mmol; 1319 mg), Xantphos (0.1721 mmol; 102.7 mg), and tris(dibenzylideneacetone)dipalladium(0) (0.1012 mmol; 93.63 mg) in 1,4-dioxane (10 mL) was purged with Argon, then sealed and stirred at 110° C. overnight. The mixture was cooled to room temperature and filtered through Celite. The filtrate was concentrated and the residue was purified on silica eluted with 0 to 20% EtOAc in DCM to afford tert-butyl N-[(3S)-1-(6-bromo-4-methyl-3-oxo-pyrazin-2-yl)-3-piperidyl]carbamate as a yellow solid (451.0 mg, 58%).

1. customwas purged with Argon
2. customsealed
3. temperatureThe mixture was cooled to room temperature
4. filtrationfiltered through Celite
5. concentrationThe filtrate was concentrated
6. customthe residue was purified on silica
7. washeluted with 0 to 20% EtOAc in DCM