HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Chloro-6,7-dimethoxy-4-quinazolinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2,4-Dichloro-6,7-dimethoxyquinazoline | HCID 520327 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Chloro-6,7-dimethoxy-4-quinazolinamine | HCID 90235 | — |
Reaction Steps
8.6 g of 2.4-Dichloro-6,7-dimethoxy quinazoline was dissolved in 300 ml of tetrahydrofuran and NH3 -gas was introduced to the solution. After saturated with NH3 -gas, the reaction mixture was allow to stand for 2 days and the solvent was removed. The resulting precipitate was collected by filtration and recrystallized from methanol. 2.8 g of desired compound was obtained. m.p. 248° C. (decomp.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04749705 |
| Source dataset | uspto-grants-1988_06 |
| ORD ID | ord-86e4921a02164407ae75c492aee910e0 |
| Source note | uspto-grants-1988_06 |