Ammonia → 2-Chloro-6,7-dimethoxy-4-quinazolinamine

HRID 579732Notes

Reaction equation

HRID 579732 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][C:6]([O:15][CH3:16])=[C:7]([O:13][CH3:14])[CH:8]=2)[N:3]=1.[NH3:17]>O1CCCC1>[Cl:1][C:2]1[N:11]=[C:10]([NH2:17])[C:9]2[C:4](=[CH:5][C:6]([O:15][CH3:16])=[C:7]([O:13][CH3:14])[CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 222Ammonia2×HCID 5203272,4-Dichloro-6,7-dimethoxyquinazoline

Product 1

HCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

8.6 g of 2.4-Dichloro-6,7-dimethoxy quinazoline was dissolved in 300 ml of tetrahydrofuran and NH3 -gas was introduced to the solution. After saturated with NH3 -gas, the reaction mixture was allow to stand for 2 days and the solvent was removed. The resulting precipitate was collected by filtration and recrystallized from methanol. 2.8 g of desired compound was obtained. m.p. 248° C. (decomp.)

Workup

  1. customthe solvent was removed
  2. filtrationThe resulting precipitate was collected by filtration
  3. customrecrystallized from methanol

Sources & evidence

ORD record
ord-86e4921a02164407ae75c492aee910e0
Source dataset
uspto-grants-1988_06
Patent number
US04749705

Reaction notes

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