HRID579734

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

结构：CCOC(=O)[C@H](CCc1ccccc1)N(C(=O)OCC(Cl)(Cl)Cl)[C@@H](C)C(=O)O

HCID13376527

未命名化合物

结构：CCOC(=O)COc1ccc(C(=O)C=C2CN[C@H](C(=O)OCC)C2)c(Cl)c1Cl

HCID57320079

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)COc1ccc(C(=O)C=C2C[C@@H](C(=O)OCC)N(C(=O)[C@H](C)N[C@@H](CCc3ccccc3)C(=O)OCC)C2)c(Cl)c1Cl

HCID67740826

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

2 次

PROCEDURE

实验过程

The acid chloride of N-((1S)-1-ethoxycarbonyl-3phenylpropyl)-N-(2,2,2-trichloroethoxycarbonyl)alanine (Example 7A) is dissolved in CH2Cl2 and added dropwise to a solution of 4-(2,3-dichloro-4-((ethoxycarbonyl)methoxy)benzoyl)methylene proline ethyl ester and triethylamine in CH2Cl2. Further reaction and purification as in example 7A gives the desired amide.

WORKUP

后处理

customFurther reaction and purification as in example 7A

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2ba06469a5484b4799245b00a0601fe7
来源数据集: uspto-grants-1988_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04749698
来源说明: uspto-grants-1988_06

反应 SMILES

[CH2:1]([O:3][C:4]([C@@H:6]([N:15](C(OCC(Cl)(Cl)Cl)=O)[C@H:16]([C:18]([OH:20])=O)[CH3:17])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])[CH3:2].[CH2:29]([O:31][C:32](=[O:56])[C@@H:33]1[CH2:37][C:36](=[CH:38][C:39](=[O:55])[C:40]2[CH:45]=[CH:44][C:43]([O:46][CH2:47][C:48]([O:50][CH2:51][CH3:52])=[O:49])=[C:42]([Cl:53])[C:41]=2[Cl:54])[CH2:35][NH:34]1)[CH3:30].C(N(CC)CC)C>C(Cl)Cl>[CH2:29]([O:31][C:32](=[O:56])[C@@H:33]1[CH2:37][C:36](=[CH:38][C:39](=[O:55])[C:40]2[CH:45]=[CH:44][C:43]([O:46][CH2:47][C:48]([O:50][CH2:51][CH3:52])=[O:49])=[C:42]([Cl:53])[C:41]=2[Cl:54])[CH2:35][N:34]1[C:18](=[O:20])[C@@H:16]([NH:15][C@H:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[CH3:17])[CH3:30]