反应详情

39.3 g of 7-acetoxy-4-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine [prepared as described in step (b) above] and 24 g of p-aminobenzonitrile were dissolved in 180 ml of ethanol, and the solution was heated under reflux for 1.5 hours. At the end of this time, the solvent was evaporated off under reduced pressure, and the resulting residue was washed with a 1:1 by volume mixture of ethanol and toluene, to give 30 g of the title compound as pale grayish crystals, melting at 215°-217° C.

1. temperaturethe solution was heated
2. temperatureunder reflux for 1.5 hours
3. customAt the end of this time, the solvent was evaporated off under reduced pressure
4. washthe resulting residue was washed with a 1:1 by volume mixture of ethanol and toluene