Methanol → AC-Pro-ome

Participants

Reaction Conditions

Reaction Steps

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of n-pentadecane internal standard, 1.0 mmol of CH3OH, 82.6 mg of (PPh3)2PdCL2, and 107.2 mg of N-acetyl-2-pyrroline. The reactor was pressurized to 1000 psi with CO at room temperature, and the reaction mixture was stirred at 100° C. for 18 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography, and the analysis indicated 98.4% conversion of N-acetyl-2-pyrroline and 36.4% yield of N-acetylproline methyl ester.

Provenance & Evidence