反应详情

温度

100 °C

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of n-pentadecane internal standard, 1.0 mmol of CH3OH, 82.6 mg of (PPh3)2PdCL2, and 107.2 mg of N-acetyl-2-pyrroline. The reactor was pressurized to 1000 psi with CO at room temperature, and the reaction mixture was stirred at 100° C. for 18 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography, and the analysis indicated 98.4% conversion of N-acetyl-2-pyrroline and 36.4% yield of N-acetylproline methyl ester.

1. customA 70 mL stainless steel high pressure reactor having
2. customwas pressurized to 1000 psi with CO at room temperature
3. temperatureThereafter, the reactor was cooled to room temperature