Benzaldehyde → 6852-57-9

HRID 579838Notes

Reaction equation

HRID 579838 reaction equation
[CH2:1]([NH2:5])[CH:2]([CH3:4])[CH3:3].[CH:6](=O)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C1C=CC=CC=1>[CH:6](=[N:5][CH2:1][CH:2]([CH3:4])[CH3:3])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 6558Isobutylamine

Product 1

HCID 118050676852-57-9Yield 89.4%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a stirred solution of isobutylamine (49.7 ml, 500 mmol) in dry benzene (50 ml) was added benzaldehyde (50.8 ml, 500 mmol) over a period of 20 minutes. After three hours, the water layer was separated and the stirring of the benzene solution continued overnight. Again the separated water layer was discarded. The benzene layer after further dilution with dry benzene (150 ml) was dried over a minimum amount of magnesium sulfate. After concentrating the dried benzene solution, the residue was distilled in vacuo, yielding 72.1 g of compound, boiling point 46°-48° C. at 0.1 mm of Hg.

Workup

  1. customthe water layer was separated
  2. waitcontinued overnight
  3. dry with materialThe benzene layer after further dilution with dry benzene (150 ml) was dried over a minimum amount of magnesium sulfate
  4. concentrationAfter concentrating the dried benzene solution
  5. distillationthe residue was distilled in vacuo

Sources & evidence

ORD record
ord-ee6bd03996a4456c88fc4dbebd772638
Source dataset
uspto-grants-1988_06
Patent number
US04749792

Reaction notes

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