Acetic Acid → HCID 14180887, compound

Participants

Reaction Steps

(S)-[4-Methyl-1-[[(2-methylpropyl)amino]acetyl]butyl]carbamic acid, 1,1-dimethylethyl ester, hydrochloride (0.66 g, 1.95 mmol) was dissolved in a solution of hydrogen chloride in acetic acid (1.5N, 7 ml) and allowed to stand at room temperature for 20 minutes. It was evaporated in vacuo and then re-evaporated from benzene. The residue was crystallized from isopropanol yielding 240 mg of the title compound, melting point 148°-150° C.

Provenance & Evidence