Acetic Acid → HCID 14180887, compound

HRID 579840Notes

Reaction equation

HRID 579840 reaction equation
[ClH:1].C[CH2:3][CH2:4][CH2:5][C@H:6]([NH:15]C(=O)OC(C)(C)C)[C:7](=[O:14])[CH2:8][NH:9][CH2:10][CH:11]([CH3:13])[CH3:12].[C:23](O)(=O)C>Cl>[ClH:1].[ClH:1].[NH2:15][C@@H:6]([CH2:5][CH:4]([CH3:3])[CH3:23])[C:7](=[O:14])[CH2:8][NH:9][CH2:10][CH:11]([CH3:12])[CH3:13]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 131715570HCID 131715570, compound

Product 1

HCID 14180887HCID 14180887, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

(S)-[4-Methyl-1-[[(2-methylpropyl)amino]acetyl]butyl]carbamic acid, 1,1-dimethylethyl ester, hydrochloride (0.66 g, 1.95 mmol) was dissolved in a solution of hydrogen chloride in acetic acid (1.5N, 7 ml) and allowed to stand at room temperature for 20 minutes. It was evaporated in vacuo and then re-evaporated from benzene. The residue was crystallized from isopropanol yielding 240 mg of the title compound, melting point 148°-150° C.

Workup

  1. customIt was evaporated in vacuo
  2. customre-evaporated from benzene
  3. customThe residue was crystallized from isopropanol yielding 240 mg of the title compound, melting point 148°-150° C.

Sources & evidence

ORD record
ord-388e42087ba84329b2f18b3f671ca3c0
Source dataset
uspto-grants-1988_06
Patent number
US04749792

Reaction notes

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