L-Aspartic Acid → HCID 178484999, compound

HRID 579844Notes

Reaction equation

HRID 579844 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5].[CH3:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH2:16][S:17][CH2:18][CH2:19]/[N:20]=[C:21](/[NH:24][C:25]#[N:26])\[NH:22][CH3:23]>ClCCl>[CH3:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH2:16][S:17][CH2:18][CH2:19]/[N:20]=[C:21](/[NH:24][C:25]#[N:26])\[NH:22][CH3:23].[NH2:1][C@H:2]([C:7]([O-:9])=[O:8])[CH2:3][C:4]([O-:6])=[O:5]

Participants

4

Reactant 2

HCID 5960L-Aspartic AcidHCID 178484997HCID 178484997, compound

Product 1

HCID 178484999HCID 178484999, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 0.66 g (0.5 cmole) of aspartic acid and 1.26 g (0.5 cmole) of cimetidine was suspended in 15 ml of dichloromethane. It was stirred for 3 hours at room temperature, filtered, washed with dichloromethane and dried. Weight 1.87 g (yield 97.5%). A stereoscopically homogenous microcrystalline white solid. M.p.: 141°-142° C. In the infra red spectrum the lines at 3200, 3130, 2160, 1620 and 1585 cm-1 are characteristic.

Workup

  1. filtrationfiltered
  2. washwashed with dichloromethane
  3. customdried

Sources & evidence

ORD record
ord-f72eacae4d254a57b5ec669506379dfd
Source dataset
uspto-grants-1988_06
Patent number
US04749790

Reaction notes

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