反应详情

温度

0 °C

To a solution of tert-butyl 3-[6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]-4-oxo-piperidine-1-carboxylate (90 mg, 0.18 mmol) in tetrahydrofuran (8.0 ml) at 0° C. was added sodium borohydride (8.0 mg, 0.20 mmol). The reaction mixture was stirred at 0° C. for 30 min. The reaction was quenched with water and extracted with EtOAc. The organic layers was dried with sodium sulfate, filtered, and concentrated in vacuum. The crude product was purified by flash chromatography (EtOAc/Heptane eluted at 100% EtOAc) to give the desired product 40 mg 44% yield. MS (ESI) m/z: 488.1.

1. customThe reaction was quenched with water
2. extractionextracted with EtOAc
3. dry with materialThe organic layers was dried with sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuum
6. customThe crude product was purified by flash chromatography (EtOAc/Heptane eluted at 100% EtOAc)