反应详情

A mixture of 3.07 grams of (S) 1,1-dimethoxy-1-(6-methoxy-2-naphthyl)prop-2-yl methanesulfonate, 1.0 gram of calcium carbonate, 100 ml. of dimethylformamide and 25 ml. of water is heated to 110° C. and maintained at that temperature for 5 hours. Then the mixture is cooled and the insolubles removed by filtration. The filtrate is poured into excess water and the solid which forms is collected by filtration. Separation by chromatography yields methyl 2-(6-methoxy-2-naphthyl)propionate, exhibiting an [α]25D =+77° in chloroform and an optical purity of greater than 99 percent.

1. temperaturemaintained at that temperature for 5 hours
2. temperatureThen the mixture is cooled
3. customthe insolubles removed by filtration
4. additionThe filtrate is poured into excess water
5. filtrationthe solid which forms is collected by filtration
6. customSeparation by chromatography