Hydrochloric Acid → 93744-72-0

HRID 579904Notes

Reaction equation

HRID 579904 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[N:6]=[C:5]([NH:10][C:11]([NH:13]NC(=O)C2C=CC=CC=2)=[S:12])[N:4]=1.[OH-].[Na+].Cl>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[N:6]=[C:5]([NH:10][C:11]([NH2:13])=[S:12])[N:4]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54321636HCID 54321636, compound

Product 1

HCID 93998193744-72-0Yield 102.5%

Procedure

A mixture of 25 g of the compound from Example 3 and 55 ml of 10% aqueous sodium hydroxide was heated on the steam bath for 30 minutes, cooled, neutralized with aqueous HCl to pH 8, filtered, washed with water, dried by suction, and washed with ether to afford 16 g of the title compound, m.p. 220° d.

Workup

  1. temperaturewas heated on the steam bath for 30 minutes
  2. temperaturecooled
  3. filtrationfiltered
  4. washwashed with water
  5. customdried by suction
  6. washwashed with ether

Sources & evidence

ORD record
ord-c13829d1f13f45e4bd71f23e498d6250
Source dataset
uspto-grants-1988_06
Patent number
US04750930

Reaction notes

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