Oxalyl chloride → HCID 85562808, compound

HRID 580039Notes

Reaction equation

HRID 580039 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[O:9][C:10]([CH2:12][C:13]([OH:15])=O)=[CH:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.C(Cl)(=O)C([Cl:19])=O>>[CH3:1][O:2][C:3]1[C:8]2[O:9][C:10]([CH2:12][C:13]([Cl:19])=[O:15])=[CH:11][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 65578Oxalyl chlorideHCID 6626195HCID 6626195, compound

Product 1

HCID 85562808HCID 85562808, compoundYield 100%

Procedure

A solution of 15.0 g of 7-methoxy-3-benzofuranacetic acid in 86 ml of oxalyl chloride was stirred at 25° for 1 hour. Removal of the solvent gave 16.35 g (100%) of crude 7-methoxy-3-benzofuranacetic acid chloride. NMR spectrum (200 mHz in CDCl3): δ4.0 (s, 3H), 4.23 (s, 2H), 6.83 (d, J=7 Hz, 1H), 7.07 (d, J=7 Hz, 1H), 7.18 (d, J=8 Hz, 1H) and 7.68 (s, 1H).

Workup

  1. customRemoval of the solvent

Sources & evidence

ORD record
ord-1178657af0ec441e8bf1b3aece7f6317
Source dataset
uspto-grants-1988_06
Patent number
US04751306

Reaction notes

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