反应详情

5 g of the 1-(1-methyl-3-phenoxypropyl)piperidine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C for 7 hours with stirring. The reaction solution was cooled and added with 20 ml of chloroform. Then, the hydrobromic acid layer was separated from the chloroform layer. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.84 g of 1-(1-methyl-3-bromopropyl)piperidine hydrobromide in a yield of 75%.

1. temperatureThe reaction solution was cooled
2. customThen, the hydrobromic acid layer was separated from the chloroform layer
3. customThe hydrobromic acid was removed under reduced pressure
4. customthe residue was recrystallized from 5 ml of ethyl alcohol