Hydrogen Bromide → 1-Methyl-3-bromopropyldiethylamine hydrobromide

HRID 580111Notes

Reaction equation

HRID 580111 reaction equation
[CH3:1][CH:2]([N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[CH2:3][CH2:4]OC1C=CC=CC=1.[BrH:17]>C(Cl)(Cl)Cl>[BrH:17].[CH3:1][CH:2]([N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[CH2:3][CH2:4][Br:17]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 135201021-Methyl-3-phenoxypropyldiethylamine

Product 1

HCID 201358451-Methyl-3-bromopropyldiethylamine hydrobromideYield 78%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5 g of the 1-methyl-3-phenoxypropyldiethylamine was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled and added with 20 ml of chloroform, and then the hydrobromic acid layer was separated from the chloroform layer. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.88 g of 1-methyl-3-bromopropyldiethylamine hydrobromide in a yield of 78%.

Workup

  1. temperatureThe reaction solution was cooled
  2. customthe hydrobromic acid layer was separated from the chloroform layer
  3. customThe hydrobromic acid was removed under reduced pressure
  4. customthe residue was recrystallized from 5 ml of ethyl alcohol

Sources & evidence

ORD record
ord-33dbe0a611ca4cad9eb5de8b4594ee0b
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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