Hydrogen Bromide → 1-Methyl-3-bromopropyldimethylamine hydrobromide

HRID 580114Notes

Reaction equation

HRID 580114 reaction equation
[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4]OC1C=CC=CC=1.[BrH:15]>C(Cl)(Cl)Cl>[BrH:15].[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4][Br:15]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 201358801-Methyl-3-phenoxypropyldimethylamine

Product 1

HCID 201357911-Methyl-3-bromopropyldimethylamine hydrobromideYield 79%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5 g of the 1-methyl-3-phenoxypropyldimethylamine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled and added with 20 ml of chloroform, and then the hydrobromic acid layer was separated from the chloroform layer. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.46 g of 1-methyl-3-bromopropyldimethylamine hydrobromide in a yield of 79%.

Workup

  1. temperatureThe reaction solution was cooled
  2. customthe hydrobromic acid layer was separated from the chloroform layer
  3. customThe hydrobromic acid was removed under reduced pressure
  4. customthe residue was recrystallized from 5 ml of ethyl alcohol

Sources & evidence

ORD record
ord-e12a4395f1a244cb9caf87dd5864593f
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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