Hydrochloric Acid → 1-(3-Diethylaminopropyl)-3-amino-4-chloroindazole dihydrochloride

HRID 580117Notes

Reaction equation

HRID 580117 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[C:11]([Cl:16])[CH:12]=[CH:13][CH:14]=2)[C:9]([NH2:17])=[N:8]1)[CH3:2].[ClH:20].C(OCC)C>C(O)C>[ClH:16].[ClH:20].[CH2:18]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[C:11]([Cl:16])[CH:12]=[CH:13][CH:14]=2)[C:9]([NH2:17])=[N:8]1)[CH3:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 132293251-(3-Diethylaminopropyl)-3-amino-4-chloroindazole

Product 1

HCID 201359051-(3-Diethylaminopropyl)-3-amino-4-chloroindazole dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 15 ml of absolute ethyl alcohol was dissolved 1.50 g of 1-(3-diethylaminopropyl)-3-amino-4-chloroindazole and into the solution was introduced dried hydrogen chloride gas under cooling with ice. To the solution was added anhydrous diethyl ether to separate crystals. Then the crystals were obtained by filtration and dried to give 1-(3-diethylaminopropyl)-3-amino-4-chloroindazole dihydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThen the crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-9499a3c793524406af36c467c22918d8
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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