Hydrochloric Acid → 1,3-Propanediamine,n3-(4-chloro-1h-indazol-3-yl)-n1,n1-diethyl-,hydrochloride

HRID 580130Notes

Reaction equation

HRID 580130 reaction equation
[CH2:1]([N:3]([CH2:6][CH2:7][CH2:8][NH:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2[Cl:19])[NH:12][N:11]=1)[CH2:4][CH3:5])[CH3:2].Cl.C(OCC)C>C(O)C>[ClH:19].[CH2:4]([N:3]([CH2:1][CH3:2])[CH2:6][CH2:7][CH2:8][NH:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2[Cl:19])[NH:12][N:11]=1)[CH3:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 201358471,3-Propanediamine,n3-(4-chloro-1h-indazol-3-yl)-n1,n1-diethyl-

Product 1

HCID 201359221,3-Propanediamine,n3-(4-chloro-1h-indazol-3-yl)-n1,n1-diethyl-,hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 4.0 g of 3-(diethylaminopropylamino)-4-chloroindazole and into the solution was introduced dried hydrogen chloride gas under cooling with ice. To the solution was added anhydrous diethyl ether to separate crystals. Then the crystals were obtained by filtration and dried to give 3-(3-diethylaminopropylamino)-4-chloroindazole hydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThen the crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-eecd6408e9974241a1809dd3c6e0b338
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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