Hydrochloric Acid → 3-(3-Diethylaminopropylamino)-5-aminoindazole dihydrochloride

HRID 580133Notes

Reaction equation

HRID 580133 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([NH2:17])[CH:15]=2)[NH:10][N:9]=1)[CH3:2].[ClH:20].C(OCC)C>C(O)C>[ClH:20].[ClH:20].[CH2:18]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([NH2:17])[CH:15]=2)[NH:10][N:9]=1)[CH3:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 201357883-(3-Diethylaminopropylamino)-5-aminoindazole

Product 1

HCID 201357873-(3-Diethylaminopropylamino)-5-aminoindazole dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 15 ml of absolute ethyl alcohol was dissolved 0.6 g of 3-(3-diethylaminopropylamino)-5-aminoindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. To the solution was added anhydrous diethyl ether to separate crystals. Then the crystals were obtained by filtration and dried to give 3-(3-diethylaminopropylamino)-5-aminoindazole dihydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThen the crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-902ca7c6c17e40c084c74154228125c2
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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