Hydrochloric Acid → 3-(3-Diethylaminopropylamino)-5-hydroxyindazole hydrochloride

HRID 580139Notes

Reaction equation

HRID 580139 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[NH:10][N:9]=1)[CH3:2].[ClH:20].C(OCC)C>C(O)C>[ClH:20].[CH2:18]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[NH:10][N:9]=1)[CH3:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 132105893-{[3-(Diethylamino)propyl]amino}-1H-indazol-5-OL

Product 1

HCID 201358513-(3-Diethylaminopropylamino)-5-hydroxyindazole hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 4.0 g of the 3-(3-diethylaminopropylamino)-5-hydroxyindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. To the solution was added anhydrous diethyl ether to separate crystals. Then the crystals were obtained by filtration and dried to give 3-(3-diethylaminopropylamino)-5-hydroxyindazole hydrochloride.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThen the crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-f6660529fc3e4eb1a5aca21ec5d5a8df
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

Loading…