Hydrochloric Acid → 3-(3-Diethylaminopropylamino)-7-iodoindazole hydrochloride

HRID 580143Notes

Reaction equation

HRID 580143 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[C:16]2[C:11](=[C:12]([I:17])[CH:13]=[CH:14][CH:15]=2)[NH:10][N:9]=1)[CH3:2].[ClH:20].C(OCC)C>C(O)C>[ClH:20].[CH2:18]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[C:16]2[C:11](=[C:12]([I:17])[CH:13]=[CH:14][CH:15]=2)[NH:10][N:9]=1)[CH3:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 20135861N~1~,N~1~-Diethyl-N~3~-(7-iodo-1H-indazol-3-yl)propane-1,3-diamine

Product 1

HCID 201358603-(3-Diethylaminopropylamino)-7-iodoindazole hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 4.0 g of the 3-(3-diethylaminopropylamino)-7-iodoindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Then to the solution was added anhydrous diethyl ether to separate crystals. The crystals were obtained by filtration and dried to give 3-(3-diethylaminopropylamino)-7-iodoindazole hydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThe crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-5c3daf6a7f004602a2e0be5c99e6eebf
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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