Hydrochloric Acid → 1-(3-Piperidinopropyl)-3-(3-diethylaminopropylamino)-5-chloroindazole dihydrochloride

HRID 580156Notes

Reaction equation

HRID 580156 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([Cl:19])=[CH:16][CH:17]=3)[C:12]([NH:20][CH2:21][CH2:22][CH2:23][N:24]([CH2:27][CH3:28])[CH2:25][CH3:26])=[N:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:29].C(OCC)C>C(O)C>[ClH:19].[ClH:29].[N:1]1([CH2:7][CH2:8][CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([Cl:19])=[CH:16][CH:17]=3)[C:12]([NH:20][CH2:21][CH2:22][CH2:23][N:24]([CH2:27][CH3:28])[CH2:25][CH3:26])=[N:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 201357691-(3-Piperidinopropyl)-3-(3-diethylaminopropylamino)-5-chloroindazole

Product 1

HCID 201358941-(3-Piperidinopropyl)-3-(3-diethylaminopropylamino)-5-chloroindazole dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 3.2 g of the 1-(3-piperidinopropyl)-3-(3-diethylaminopropylamino)-5 -chloroindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Then to the solution was added anhydrous diethyl ether to separate crystals. The crystals were obtained by filtration and dried to give 1-(3-piperidinopropyl)-3-(3-diethylaminopropylamino)-5-chloroindazole dihydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThe crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-a7691a61a5d34c2ba1410eacc76909e0
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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