Hydrochloric Acid → 1-(3-Dimethylaminobutyl)-3-(3-diethylaminopropylamino)5-chloroindazole dihydrochloric acid

HRID 580161Notes

Reaction equation

HRID 580161 reaction equation
[CH3:1][N:2]([CH3:26])[CH:3]([CH3:25])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([Cl:15])=[CH:12][CH:13]=2)[C:8]([NH:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])=[N:7]1.[ClH:27].C(OCC)C>C(O)C>[ClH:15].[ClH:27].[CH3:26][N:2]([CH3:1])[CH:3]([CH3:25])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([Cl:15])=[CH:12][CH:13]=2)[C:8]([NH:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])=[N:7]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 201358711-(3-Dimethylaminobutyl)-3-(3-diethylaminopropylamino)-5-chloroindazole

Product 1

HCID 201358701-(3-Dimethylaminobutyl)-3-(3-diethylaminopropylamino)5-chloroindazole dihydrochloric acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 3.10 g of the 1-(3-dimethylaminobutyl)-3-(3-diethylaminopropylamino)-5-chloroindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Then to the solution was added anhydrous diethyl ether to separate crystals. The crystals were obtained by filtration and dried to give 1-(3-dimethylaminobutyl)-3-(3-diethylaminopropylamino)5-chloroindazole dihydrochloric acid having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThe crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-740b391f14154cd684c5c3aa27247e97
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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