Hydrochloric Acid → HCID 20135761, compound

HRID 580177Notes

Reaction equation

HRID 580177 reaction equation
[N:1]1([CH:7]([CH3:29])[CH2:8][CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([OH:19])=[CH:16][CH:17]=3)[C:12]([NH:20][CH2:21][CH2:22][CH2:23][N:24]([CH2:27][CH3:28])[CH2:25][CH3:26])=[N:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:30].C(OCC)C>C(O)C>[ClH:30].[ClH:30].[N:1]1([CH:7]([CH3:29])[CH2:8][CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([OH:19])=[CH:16][CH:17]=3)[C:12]([NH:20][CH2:21][CH2:22][CH2:23][N:24]([CH2:27][CH3:28])[CH2:25][CH3:26])=[N:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 13210617HCID 13210617, compound

Product 1

HCID 20135761HCID 20135761, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 4.0 g of the 1-(3-piperidinobutyl)-3-(3-diethylaminopropylamino)-5-hydroxyindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Then to the solution was added anhydrous diethyl ether to separate crystals. The crystals were obtained by filtration and dried to give 1-(3-piperidinobutyl)-3-(3-diethylaminopropylamino)-5-hydroxyindazole dihydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThe crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-d8b7a093073c44aa9a1e2003f08f7b2c
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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