Hydrochloric Acid → HCID 20135818, compound

HRID 580180Notes

Reaction equation

HRID 580180 reaction equation
[CH3:1][N:2]([CH3:26])[CH:3]([CH3:25])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([OH:15])=[CH:12][CH:13]=2)[C:8]([NH:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])=[N:7]1.[ClH:27].C(OCC)C>C(O)C>[ClH:27].[ClH:27].[CH3:26][N:2]([CH3:1])[CH:3]([CH3:25])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([OH:15])=[CH:12][CH:13]=2)[C:8]([NH:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])=[N:7]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 13210621HCID 13210621, compound

Product 1

HCID 20135818HCID 20135818, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 3.8 g of the 1-(3-dimethylaminobutyl)-3-(3-diethylaminopropylamino)-5-hydroxyindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Then to the solution was added anhydrous diethyl ether to separate crystals. The crystals were obtained by filtration and dried to give 1-(3-dimethylaminobutyl)-3-(3-diethylaminopropylamino)-5-hydroxyindazole dihydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThe crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-a1378b8c389443b5a6aa97ff325ad35d
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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