Hydrochloric Acid → 3-Amino-4-hydroxyindazole hydrochloride

HRID 580189Notes

Reaction equation

HRID 580189 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[OH:11])[NH:4][N:3]=1.[ClH:12].C(OCC)C>C(O)C>[ClH:12].[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[OH:11])[NH:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 1355831063-Amino-1H-indazol-4-ol

Product 1

HCID 1355831073-Amino-4-hydroxyindazole hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 3.5 g of the 3-amino-4-hydroxyindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Then to the solution was added anhydrous diethyl ether to separate crystals. The crystals were obtained by filtration and dried to give 3-amino-4-hydroxyindazole hydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThe crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-6259ff2684d247279678b0ce3e44d672
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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