HCID 72729003, compound → HCID 54294179, compound

HRID 580221Notes

Reaction equation

HRID 580221 reaction equation
C(OC([NH:8][C:9]1[S:13][N:12]=[C:11]([C:14](=[N:18][O:19][CH2:20][C:21]#[CH:22])[C:15]([OH:17])=[O:16])[N:10]=1)=O)(C)(C)C>FC(F)(F)C(O)=O>[NH2:8][C:9]1[S:13][N:12]=[C:11]([C:14](=[N:18][O:19][CH2:20][C:21]#[CH:22])[C:15]([OH:17])=[O:16])[N:10]=1

Participants

3

Reactant 1

HCID 72729003HCID 72729003, compound

Product 1

HCID 54294179HCID 54294179, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 410 mg (1.26 mmoles) of 2-(5-t-butoxycarbonylamino-1,2,4-thiadiazol-3-yl)-2-propargyloxyiminoacetic acid in 5 ml of trifluoroacetic acid was allowed to stand for 1 hour at 25° C. Evaporation followed by trituration of the residue with 25 ml of isopropyl ether gave 204 mg (72%) of the title compound. Mp. 156°-158° C. (dec.).

Workup

  1. customEvaporation

Sources & evidence

ORD record
ord-1225313926b64bdc936163477c2d1fd6
Source dataset
uspto-grants-1988_06
Patent number
US04751295

Reaction notes

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