反应详情

A mixture of 1-(2-fluoro-4-chloro-5-hydroxyphenyl)-3,4,5-trimethylpyrazole (25.5 g), allyl bromide (13.3 g), anhydrous potassium carbonate (14.5 g) and acetonitrile (150 ml) was heated under reflux, with stirring for 3 hours. After cooling, the reaction mixture was filtered through a filter to remove the inorganic salts therefrom and the filtrate was concentrated to a small volume under reduced pressure, affording the titled compound (28.7 g) as a pale brown crystalline solid. Recrystallization of this solid from cyclohexane yielded a white crystalline solid. m.p. 97°-99° C.

1. temperaturewas heated
2. temperatureunder reflux
3. temperatureAfter cooling
4. filtrationthe reaction mixture was filtered through
5. filtrationa filter
6. customto remove the inorganic salts
7. concentrationthe filtrate was concentrated to a small volume under reduced pressure