Hydrogen chloride-ethyl acetate → HCID 131736963, compound

Participants

Reaction Steps

N-t-butyloxycarbonyl-D,L-isoleucyl-L-proline benzyl ester (13 g) was dissolved in ethyl acetate (34 ml), and 15% HCl/ethyl acetate solution (25 ml) was added dropwisely upon cooled. After the completion of addition, the resulting mixture was allowed to warm up naturally to room temperature to react for 4 h, and then concentrated under reduced pressure to remove the reaction liquid, and the oil was recrystallized with isopropanol/n-hexane to give 4.5 g white solid (90%), with the content being 94% (HPLC, mobile phase 1, method 2).

Provenance & Evidence