反应详情

N-t-butyloxycarbonyl-D,L-isoleucyl-L-proline benzyl ester (13 g) was dissolved in ethyl acetate (34 ml), and 15% HCl/ethyl acetate solution (25 ml) was added dropwisely upon cooled. After the completion of addition, the resulting mixture was allowed to warm up naturally to room temperature to react for 4 h, and then concentrated under reduced pressure to remove the reaction liquid, and the oil was recrystallized with isopropanol/n-hexane to give 4.5 g white solid (90%), with the content being 94% (HPLC, mobile phase 1, method 2).

1. temperatureupon cooled
2. additionAfter the completion of addition
3. customto react for 4 h
4. concentrationconcentrated under reduced pressure
5. customto remove
6. customthe reaction liquid
7. customthe oil was recrystallized with isopropanol/n-hexane