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0 °C

D,L-isoleucyl-L-proline benzyl ester hydrochloride (1.2 g) was dissolved in dichloromethane (10 ml), cooled down to 0° C., and DIEA (860 mg) and benzoyl chloride (477 mg) were added dropwisely. The resulting mixture was allowed to warm up naturally to room temperature to react for 2 h, concentrated under reduced pressure to remove the solvent, and purified on a column to give a pale yellow oil (1.1 g, 79%).

1. temperatureto warm up naturally to room temperature
2. customto react for 2 h
3. concentrationconcentrated under reduced pressure
4. customto remove the solvent
5. custompurified on a column