反应详情

To a solution of 4-chloro-6-methyl-2-(6-n-propyl-2-pyridinyl)pyrimidine (2 g) in ethyl alcohol (50 ml), was added 5 % palladium carbon (0.2 g). The mixture was brought into contact with hydrogen gas for two hours. After palladium carbon was filtered off, the reaction solution was concentrated under reduced pressure to give a residue. To the residue, was added saturated aqueous sodium bicarbonate solution (30 ml). The mixture was extracted with chloroform (100 ml) and dried over anhydrous magnesium sulfate. The extract was concentrated under reduced pressure to obtain 4-methyl-2-(6-n-propyl-2-pyridinyl)pyrimidine (1.53 g, yield: 89 %).

1. filtrationAfter palladium carbon was filtered off
2. concentrationthe reaction solution was concentrated under reduced pressure
3. customto give a residue
4. extractionThe mixture was extracted with chloroform (100 ml)
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationThe extract was concentrated under reduced pressure