反应详情

To solution of 4-hydroxy-6-methyl-2-(6-n-propyl-2-pyridinyl)pyrimidine (2 g) in toluene (20 ml), was added phosphoryl chloride (2 g). The mixture was heated under refluxing for one hour and left to stand to room temperature. Aqueous sodium carbonate solution was added thereto until the reaction solution became about pH 8 to be separated into two layers. Toluene layer was collected and washed with water and dried over anhydrous magnesium sulfate. The toluene layer was concentrated under reduced pressure to obtain 4-chloro-6-methyl-2-(6-n-propyl-2-pyridinyl)pyrimidine (2.03 g).

1. temperatureThe mixture was heated
2. temperatureunder refluxing for one hour
3. waitleft
4. customto stand to room temperature
5. customto be separated into two layers
6. customToluene layer was collected
7. washwashed with water
8. dry with materialdried over anhydrous magnesium sulfate
9. concentrationThe toluene layer was concentrated under reduced pressure