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HRID580339

反应详情

EQUATION

反应方程式

HRID 580339 的结构方程式

REACTANTS

反应物

3
结构：Nc1ccc(C(F)(F)F)cc1
HCID9964

4-(Trifluoromethyl)aniline

C7H6F3N

结构：CCOC(=O)CSC
HCID78199

Ethyl (methylthio)acetate

C5H10O2S

结构：CC(C)(C)OCl
HCID521297

Hypochlorous acid, 1,1-dimethylethyl ester

C4H9ClO

PRODUCTS

生成物

1
结构：O=C1Cc2cc(C(F)(F)F)ccc2N1
HCID3734457

5-(Trifluoromethyl)-1,3-dihydro-2H-indol-2-one

C9H6F3NO

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Ni]
催化剂HCID935

Nickel

Ni

结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

In analogous fashion, 4-trifluoromethylaniline was reacted with t-butyl hypochlorite, ethyl 2-(methylthio)acetate and triethylamine followed by reduction of the 3-thiomethyl-5-trifluoromethyl-2-oxindole thus obtained with Raney nickel, to give 5-trifluoromethyl-2-oxindole, m.p. 189.5°-190.5° C.