反应详情

A mixture of 5-bromo-1-methylpyrimidine-2,4(1H,3H)-dione (200 mg, 0.976 mmol), 2-bromoacetamide (162 mg, 1.171 mmol) and K2CO3 (162 mg, 1.171 mmol) in DMSO (4 mL) was stirred at room temperature for 4 hours. The reaction mixture was subsequently filtered and purified via preparative HPLC, eluting with a gradient of 1-40% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA) to give the title compound.

1. filtrationThe reaction mixture was subsequently filtered
2. custompurified via preparative HPLC
3. washeluting with a gradient of 1-40% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA)