HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 86742239, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3-Oxo-butyric acid 4-cyclohexylpiperazide | HCID 86162482 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86742239 | HCID 86742239 | — |
Reaction Steps
0.1 mol of crude 3-oxo-butyric acid 4-cyclohexylpiperazide is dissolved in 150 ml of tetrahydrofuran and, under reflux, after addition of 0.5 g of p-toluenesulphonic acid, ammonia is passed in for 4 hours. The mixture is allowed to stand at room temperature overnight, the solvent is removed by distillation in vacuo, and the residue is crystallized from toluene/petroleum ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04753936 |
| Source dataset | uspto-grants-1988_06 |
| ORD ID | ord-0175a7ef9dff4529ae0f906735ed263f |
| Source note | uspto-grants-1988_06 |